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M9630036.TXT
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1996-02-27
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Document 0036
DOCN M9630036
TI [The effect of the blood serum factors of HIV-infected persons on the
functional activity of the neutrophils in healthy donors]
DT 9603
AU Gabrilovich DI; Ivanova LA; Shepeleva GK; Serebrovskaia LV; Buravtsova
EV; Pokrovskii VV
SO Zh Mikrobiol Epidemiol Immunobiol. 1995 Sep-Oct;(5):56-60. Unique
Identifier : AIDSLINE MED/96093393
AB The influence of 64 blood serum samples from HIV-infected patients at
different stages of the infection on the functional activity of
polymorphonuclear neutrophils (PMN) of 9 healthy donors was studied. In
this study an increase in the production of oxygen radicals by PMN of
the donors was revealed (in the chemiluminescence test), positive
correlations between this increase and stages of HIV infection were
followed. The presence of HIV-positive serum in the incubation medium
led to the inhibition of phagocytosis and produced almost no changes in
the capacity of PMN for its completion. A decrease in phagocytosis
correlated with the level of complement and did not depend on other
serum factors; on the contrary, an increase in chemiluminescence was not
linked with the levels of complement, but had correlative relationships
with the levels of anti-HIV antibodies and circulating immune complexes.
DE Adolescence Adult *Blood Donors Chemiluminescence Comparative Study
English Abstract Female Free Radicals/BLOOD Human HIV
Infections/*BLOOD *HIV-1 Male Neutrophil Activation/*PHYSIOLOGY
Neutrophils/METABOLISM Oxygen/BLOOD Phagocytosis JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).